Ketosteril for renal failure in cats

A supplement called ketosteril may be beneficial for cats with renal issues. Renal failure in cats causes problems for the kidneys in filtering waste from the blood, which can cause major health problems. By giving the body vital nutrients and preventing the accumulation of dangerous substances, ketosteril aids.

Ketosteril’s ability to support a cat’s nutrition without placing additional strain on their kidneys is one of its key advantages. It has low-nitrogen amino acids in it, which helps stop waste from forming that damaged kidneys can’t adequately remove.

Ketosteril may be a significant component of your cat’s treatment regimen if they have been diagnosed with renal failure. But since each cat is unique, it’s wise to speak with your veterinarian before beginning any new supplement regimen.

Composition, release forms and storage conditions of Ketosteril

The German company Fresenius Kabi Deutschland GmbH is the creator of Ketosteril.

Ketosteril comes in yellow, long, biconvex tablets with a thin film covering them. The tablets are arranged in 20-piece blisters, five of which are sealed in polymer and aluminum bags before being packaged in a cardboard box.

Every tablet has the following contents:

• Active substances:

• Isolecin α-Ketoanalog (DL-methyl-ox-2-calcium valerinate)-67 mg;
• Leucine α-Ketoanalog (methyl-4-ox-2-calcium valerinate)-101 mg;
• phenylalanin α-Ketoanalog (OKSO-2-Fenil-3-calcium propionate)-68 mg;
• Valina α-Ketoanalog (methyl-ox-2-calcium Butirate)-86 mg;
• metionine α-hydroxyanalog (DL-hydroxy-2-calcium methylbutirate)-59 mg;
• L-lysine monoacetate-105 mg;
• L-traine-53 mg;
• L-tripthophanes-23 mg;
• L-hyistidine-38 mg;
• L-tyrosin-30 mg.

• corn starch – 44 mg;
• Povidon – 6 mg;
• talc – 19.57 mg;
• silicon dioxide colloidal – 4.4 mg;
• Magnesium stearate – 15 mg;
• macrogol 6000 – 12.8 mg;
• soluble povidone – 43.2 mg.

• talc — 9.1 mg;
• macrogol 6000 — 1.48 mg;
• quinoline yellow (E104) — 0.72 mg;
• methyl methacrylate copolymer;
• dimethylaminoethyl methacrylate and butyl methacrylate (eudragit E12.5) — 5.9 mg;
• triacetin — 0.43 mg;
• titanium dioxide — 7.4 mg.

36 mg of nitrogen in total. 50 mg of calcium in total.

Each Ketosteril pack has one hundred tablets.

After it is manufactured, ketosteril can be stored for three years as long as the following criteria are met:

• protection from moisture;
• darkness;
• out of reach of children;
• temperature regime not higher than 25 o C.

Indications for the use of Ketosteril in cats

When a low-protein diet is followed, ketosteril is prescribed to treat and prevent disorders related to protein metabolism in patients with chronic renal failure.

The progressive demise of the kidneys’ structural units, or nephrons, and their replacement by connective tissue, are the hallmarks of chronic renal failure. Nephron loss is irreversible, and the kidneys are incapable of regeneration. Therefore, reducing metabolic disorders that result from renal failure and slowing down the process of nephron loss are the main goals of therapy. The current stage of renal failure and the effectiveness of therapy targeted at eradicating metabolic disorders resulting from the disease both impact the pet’s prognosis for the remainder of its life.

Conditions that cause chronic renal failure to develop include:

• glomerulonephritis – pathologies of infectious-allergic origin, in which the body"s own immune system is involved in damage to kidney tissue;
• pyelonephritis – infectious and inflammatory kidney lesions, when a bacterial infection spreads to the kidney from the renal pelvis;
• polycystic kidney disease is a developmental defect of the kidneys, in which normal tissue is practically absent, the kidney contains cysts (hollow fluid formations prone to suppuration);

Chronic renal failure is caused by multiple cysts in the renal tissue.

Renal failure progresses through several stages during its development:

• Initial – creatinine content does not exceed 250 μmol / l. Symptoms:

• deterioration of appetite;
• episodic vomiting;
• dry skin.

• depression;
• noticeable increase in the amount of urine excreted;
• dehydration;
• nausea, vomiting;
• diarrhea.

• excretion of large amounts of dilute urine;
• severe dehydration;
• anemia;
• hypertension;
• exhaustion;
• nausea, vomiting;
• diarrhea;
• encephalopathy;
• heart failure;
• convulsions.

As per the medication’s instructions, patients should take ketosteril if their kidneys’ glomerular filtration rate is less than 25 milliliters per minute. However, in animals, this indicator is not measured because there aren’t any trustworthy or readily available methods. Although the medication can be administered to patients at an earlier stage of the disease, if glomerular filtration rate is the primary concern, it should be used in the terminal stage.

There are twenty yellow, long, biconvex Ketosteril tablets in each blister.

Video: symptoms of kidney failure in cats

How Ketosteril works

The cat receives amino acids from ketosteril that have an exceptionally low nitrogen content. Compared to humans or dogs, cats require proteins far more frequently, and they have a limited capacity to adjust to their low dietary content.

The composition of Ketosteril does not fully reflect the needs of the cat"s protein metabolism. It does not contain taurine and arginine, which are not synthesized in the liver of cats, unlike humans. If renal function is impaired, pets are kept on a special veterinary diet with a minimum amount of protein to prevent an increase in the level of toxic products of protein metabolism (which are normally excreted by the kidneys) and worsening of the disease. In this case, there is a deficiency of this substance in the body, since protein molecules wear out and need periodic renewal. They consist of amino acids that enter the cat"s body with food. Some amino acids can be synthesized in the liver, while the liver cannot synthesize other parts (essential amino acids), and they are the most valuable. With a low-protein diet, all amino acids are deficient.

Toxic ammonia is released in the liver as a result of the protein molecule’s utilization, and this ammonia is then transformed into urea. Renal failure impairs its excretion, causing it to build up in the blood. Conversely, in order for the active ingredients in ketosteril to change into amino acids, they require a portion of the urea molecule. Thus, the medication lowers the level of urea while simultaneously enhancing protein synthesis. Furthermore, there is a decrease in the markers of uremic intoxication, which is the body’s own waste product poisoning. These markers include the blood levels of:

• phosphates;
• potassium ions;
• magnesium ions.

Pets with kidney pathology exhibit positive dynamics during the course of the disease when given a course of therapy. For kidney disease, ketosteril is used in conjunction with medication therapy.

It should be noted that ketosteril effectively treats the metabolic disorders associated with the disease, primarily those involving protein synthesis, while also lowering the level of uremic toxins. However, it has no effect on the underlying cause of the disease.

When you take ketosteril, you can:

• resist exhaustion, which naturally develops with a decrease in renal function;
• reduce the loss of muscle mass, including myocardium;
• support the function of the immune system (after all, antibodies are proteins);
• improve digestion (digestive enzymes are also protein compounds).

Features of using Ketosteril in cats

Cats are prescribed ketosteril by their veterinarians.

Dosage selection

A veterinarian determines the exact dosage of Ketosteril for each cat, as the instructions solely address how the medication is to be used in humans. Veterinarians generally follow the human instructions, which call for a daily dosage of 100 mg/kg of weight; however, they may vary this based on the specifics of a given clinical scenario. For example, a 5 kg cat needs 1 Ketosteril tablet per day.

Because the contents of the dosage form are shielded by the shell from the damaging effects of gastric juice on amino acids, the manufacturer does not recommend splitting the tablet for use in smaller pets, which makes it inconvenient for use in cats.

Table: selection of Ketosteril dosage for a cat

Cat weight	Ketosteril dosage, per day
2.5 kg	0.5 tablets
5 kg	1 tablet
7.5 kg	1.5 tablets
10 kg	2 tablets

Administration scheme

Cats are typically given ketosteril twice a day, either right before or right after feeding. Although Ketosteril’s manufacturer advises taking the medication for the duration of reduced glomerular filtration, in reality, prescriptions for it are frequently given for life. It’s also crucial to remember that Ketosteril is administered while the cat is being fed veterinary diets from the Renal line.

Cats with renal failure can take the Renal line of therapeutic foods.

Precautions

The following guidelines need to be followed when using ketosteril:

• during the course of therapy with Ketosteril, laboratory monitoring of the blood content is necessary:

• calcium, since there is a risk of its increase;
• phosphates, since they will decrease;

It should be mentioned that you shouldn’t take more Ketosteril than is recommended in order to see results more quickly. Doing so will increase proteinuria, or the presence of protein in the urine, and worsen the progression of urolithiasis.

Features of use in pregnant cats and kittens

When the advantages of using ketosteril outweigh the risks, pregnant cats and small kittens should take the medication as directed by their veterinarian and under their supervision. This medication’s effects on small kittens and pregnant cats have not been thoroughly researched.

Video: treatment of chronic renal failure in cats

Contraindications and side effects of Ketosteril

The following are reasons not to take ketosteril:

• increased calcium levels in the blood;
• impaired amino acid metabolism;
• individual hypersensitivity to the components of the drug.

The potential for elevated blood calcium levels is a side effect. There are no known signs of a ketosteril overdose.

As a supplement that provides essential amino acids without adding extra protein that may be difficult for the kidneys of cats suffering from renal failure to process, ketosteril is frequently used to support these patients. When combined with a therapy plan prescribed by a veterinarian, it can help your cat’s quality of life and slow the disease’s progression. Before giving your cat any new supplements, always get advice from your veterinarian.

Drug interactions

Ketosteril interacts with the following medications:

• When used together with calcium-containing products, it is possible to increase calcium levels in the blood.
• When the level of nitrogenous wastes decreases under the influence of the drug Ketosteril, the dose of aluminum hydroxide used together should be reduced.
• In order not to disrupt the absorption of Ketosteril in the intestine, it should not be used simultaneously with compounds that interact with calcium and prevent its dissolution. After taking these drugs, Ketosteril can be used no earlier than 2 hours later. These include:

• tetracyclines;
• quinolones;
• iron preparations;

If your pet is prescribed oral iron supplements, they should be given two hours apart from ketosteril.

Table: comparison of Ketosteril and its analogue

• isoleucine α-keto analogue (DL-methyl-oxo-2-calcium valerinate) – 67 mg;
• leucine α-keto analogue (methyl-4-oxo-2-calcium valerinate) – 101 mg;
• phenylalanine α-keto analogue (oxo-2-phenyl-3-calcium propionate) – 68 mg;
• valine α-keto analogue (methyl-oxo-2-calcium butyrate) – 86 mg;
• methionine α-hydroxy analogue (DL-hydroxy-2-calcium methylbutyrate) – 59 mg;
• L-lysine monoacetate – 105 mg;
• L-threonine – 53 mg;
• L-tryptophan – 23 mg;
• L-histidine – 38 mg;
• L-tyrosine – 30 mg.

• increased calcium levels in the blood;
• amino acid metabolism disorder;
• individual hypersensitivity to the components of the drug.

A complete analogue of ketosteril, but slightly less expensive, is the medication ketoaminol.

Complete analogue of ketosteril is ketoaminol.

Reviews of cat owners

Ketoamilon is an analogue of ketosteril? Analogues have been around for a long time, when I worked at the Blood Transfusion Research Institute, doctors told me that analogues should not be taken, they often do not work, and you do not have time for experiments … Ketosteril is not prescribed because they do not have it in the treatment regimen. People are prescribed it for CRF, and it helps, but there have been no studies on whether it helps dogs and cats, so they have no right to prescribe it. However, many dogs and cats with CRF survive exclusively on ketosteril and it significantly prolongs their lives.

Overt7

/forum/index.php?showtopic=192073&st=220 pesikot.org

The question is a little incorrect, CRF can be very different and for different reasons, ketosteril regulates nitrogen metabolism and something else there, so that "on ketosteril" to live, and without it to die – there is no such thing. It is used as part of complex therapy. These are amino acids, what side effects are there … Calcium may increase, but electrolytes in any case must be monitored if there are problems with the kidneys. Your friend"s cat was prescribed it, as I understand, as a preventive measure for now, to support the kidneys? The best thing is to catch the disease at the beginning. I know cats that have lived with chronic renal failure for many years, taking ketosteril, but this is chronic renal failure without aggravating circumstances – anemia, high phosphorus, hypertension, etc., ketosteril did not affect the situation in cats with these problems ((

Goldcrest

Forum.ngs24.ru/board/leavingandhealth/flat/2026934281/?fpart=1&page-count=50

Aspect	Description
What is Ketosteril?	A supplement used to manage renal failure in cats by providing essential amino acids and reducing the strain on the kidneys.
How does it help?	Ketosteril helps to prevent protein buildup in the blood and supports the kidneys by reducing the production of harmful waste products.
When is it used?	It is typically given when a cat has chronic kidney disease and needs help maintaining proper nutrition without overloading the kidneys.
How to give it?	Ketosteril is usually administered orally, often mixed with food, and the dosage depends on the severity of the cat’s kidney condition.
Side effects	Side effects are rare but may include digestive issues like vomiting or diarrhea in some cats.

For cats suffering from renal failure, ketosteril can be a beneficial supplement that supports their health by supplying vital amino acids without putting additional strain on their kidneys. It functions by assisting in the removal of dangerous toxin accumulation from the body, which is important for the treatment of persistent kidney problems.

Although ketosteril is not a cure, when used in conjunction with other comprehensive treatment, it can help your cat live a better quality of life. It’s crucial to heed your veterinarian’s advice regarding dosage and to keep a close eye on your cat’s health while using it.

While your cat is on ketosteril, always contact your veterinarian as soon as you notice any changes in their behavior or overall health. The long-term health of your cat depends on making sure they are at ease and reacting favorably to the treatment.

Video on the topic

How to reduce creatinine | advice from a nephrologist

Ketosteril

FIRST AID KIT | Ketosteril